Effects of genetic polymorphisms of GSTM1, GSTT1, and GSTP1 genes on blood metal levels in non-ferrous metal alloy smelter operators

Heavy metal ions are known to induce generation of a large number reactive oxygen species (ROS). Glutathione S-transferases (GSTs) play an important role in adaptation and response oxidative stress. GSTM1, GSTT1, GSTP1 genes have numerous described polymorphisms, the most significant being Ile105Val deletion ones. Our objective was study relationship between genetic polymorphism blood levels metals smelter operators engaged crude lead refining. We examined 55 male lead-refining furnace working at non-ferrous alloy plant. Blood concentrations were measured by inductively coupled plasma mass spectrometry. GSTM1 GSTT1 polymorphisms determined using real-time SYBR Green qPCR that – commercial SNP Screening Kit. Statistical data processing carried out Mann Whitney U-test. industry-specific not statistically different workers with genotypes. established, however, men null genotype had significantly higher arsenic levels. findings indicate high level associated occupational exposure may be attributed genotype. This observation can used identify vulnerable groups individuals risk overexposure arsenic.